卢乃浩,男,博士,副教授(低职高聘教授)。2010年6月华中科技大学生物无机化学专业毕业获博士学位,2010年7月至今任江西师范大学教师,2016年1月至2017年1月在美国休斯敦大学进行访问学者研究。目前主持在研国家自然科学基金项目两项,已主持完成国家自然科学基金和江西省自然科学基金项目各两项,江西师范大学首批青年英才人选,2015年度江西省百人远航工程人选,获得2017年度江西省杰出青年人才资助计划。
研究成果已经在相关领域的国际期刊Free Radical Biol Med,J Agric Food Chem, J Biol Inorg Chem,Chem Res Toxicol,Arch Biochem Biophys,Biochem Biophys Res Commun等发表SCI 论文30 余篇,其中IF>3的10篇。欢迎有志于从事化学生物学研究的研究生和本科生同学加入本课题组一起工作学习!联系方式:naihaolu@jxnu.edu.cn
研究方向:
(1) 有机(黄酮类、天然有机化合物,碳纳米管)、无机分子(NaNO2)与蛋白质的相互作用及其化学生物学效应;
(2) 氨基酸翻译后修饰与蛋白质结构和功能、以及疾病发生发展的关系。
近年来主持的科研项目:
1. 国家自然科学基金(31760255):亚硝酸钠对NADPH氧化酶介导的氧化应激调控机制的研究(直接经费38万),2018/01-2021/12,主持在研
2. 国家自然科学基金(31560255):血浆蛋白质在髓过氧化物酶生物降解单壁碳纳米管中影响机制的研究(50.4万),2016/01-2019/12,主持在研
3. 国家自然科学基金(31260216):亚硝酸钠对髓过氧化物酶催化氯化反应的抑制作用及其与老年痴呆症的关系研究(48万),2013/01-2016/12,已结题
4. 国家自然科学基金(31100608):髓过氧化物酶通过催化蛋白质氯化影响糖尿病心血管并发症病理过程的研究(20万),2012/01-2014/12,已结题
5. 江西省杰出青年人才资助计划(20171BCB23041)(15万元),2018/01-2021/01,主持在研
6. 江西省自然科学基金(20161BAB215215):已结题
7. 江西省自然科学基金(20114BAB204013):已结题
8. 江西省科学技术学会2015年度“百人远航工程”:已完成
9. 中国博士后科学基金(2013M531557):已结题
10. 江西省教育厅科研项目(GJJ12183):已结题
发表的代表性论文:
1. Rong Tian, Yun Ding, Yi-Yuan Peng, Naihao Lu*. Inhibition of Myeloperoxidase- and Neutrophil-Mediated Hypochlorous Acid Formation in Vitro and Endothelial Cell Injury by (-)-Epigallocatechin Gallate. Journal of Agricultural and Food Chemistry. 2017, 65(15): 3198-3203.
2. Yun Ding, Rong Tian, Zhen Yang, Jianfa Chen, Naihao Lu*. Effects of serum albumin on the degradation and cytotoxicity of single-walled carbon nanotubes. Biophysical Chemistry. 2017, 222: 1-6.
3. Yun Ding, Rong Tian, Zhen Yang, Jianfa Chen, Naihao Lu*. NADPH oxidase-dependent degradation of single-walled carbon nanotubes in macrophages. Journal of Materials Science: Materials in Medicine. 2017, 28(1): 7.
4. Yun Ding, Rong Tian, Zhen Yang, Jianfa Chen, Naihao Lu*. Binding of human IgG to single-walled carbon nanotubes accelerated myeloperoxidase-mediated degradation in activated neutrophils. Biophysical Chemistry. 2016, 218: 36-41.
5. Naihao Lu*, Yun Ding, Rong Tian, Zhen Yang, Jianfa Chen, Yi-Yuan Peng*. Effects of pharmacological ascorbate on hemoglobin-induced cancer cell proliferation. International Journal of Biological Macromolecules. 2016, 92: 1215-1219.
6. Naihao Lu*, Yun Ding, Zhen Yang, Pingzhang Gao*. Effects of rutin on the redox reactions of hemoglobin. International Journal of Biological Macromolecules. 2016, 89: 175-180.
7. Naihao Lu*, Yun Ding, Rong Tian, Yi-Yuan Peng*. Inhibition of myeloperoxidase-mediated oxidative damage by nitrite in SH-SY5Y cells: Relevance to neuroprotection in neurodegenerative diseases. European Journal of Pharmacology. 2016, 780: 142-147.
8. Xiaoming Ren, Yun Ding, Naihao Lu*. Nitrite attenuated peroxynitrite and hypochlorite generation in activated neutrophils. European Journal of Pharmacology. 2016, 775: 50-56.
9. Naihao Lu*, Qin Yang, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Inhibitory effect of human serum albumin on Cu-induced Aβ40 aggregation and toxicity. European Journal of Pharmacology. 2015, 767: 160-164.
10. Naihao Lu*, Jiayu Li, Zhonghong Gao*. Key roles of Tyr 10 in Cu bound Aβ complexes and its relevance to Alzheimer's disease. Archives of Biochemistry and Biophysics. 2015, 584: 1-9.
11. Naihao Lu*, Jiayu Li, Xiaoming Ren, Rong Tian, Yi-Yuan Peng*. Nitrite attenuated hypochlorous acid-mediated heme degradation in hemoglobin. Chemico-Biological Interactions. 2015, 238: 25-32.
12. Naihao Lu*, Shiliang Xie, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Myeloperoxidase-mediated oxidation targets serum apolipoprotein A-I in diabetic patients and represents a potential mechanism leading to impaired anti-apoptotic activity of high density lipoprotein. Clinica Chimica Acta. 2015, 441: 163-170.
13. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles for tyrosine 10 in Aβ-heme complexes and its relevance to oxidative stress. Chemical Research in Toxicology. 2015, 28(3): 365-372.
14. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Key roles of Arg5, Tyr10 and His residues in Aβ-heme peroxidase: Relevance to Alzheimer's disease. Biochemical and Biophysical Research Communications. 2014, 452(3): 676-681.
15. Naihao Lu*, Jiayu Li, Rong Tian, Yi-Yuan Peng*. Binding of human serum albumin to single-walled carbon nanotubes activated neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes. Chemical Research in Toxicology. 2014, 27(6): 1070-1077.
16. Naihao Lu*, Jiayu Li, Yingjie He, Rong Tian, Qiang Xiao*. Nitrative modifications of α-enolase in hepatic proteins from diabetic rats: The involvement of myeloperoxidase. Chemico-Biological Interactions. 2014, 220: 12-19.
17. Naihao Lu*, Chao Chen, Yingjie He, Rong Tian, Qiang Xiao, Yi-Yuan Peng*. The dual effects of nitrite on hemoglobin-dependent redox reactions. Nitric Oxide. 2014, 40: 1-9.
18. Naihao Lu*, Yingjie He, Chao Chen, Rong Tian, Qiang Xiao*, Yi-Yuan Peng. Tyrosine can protect against oxidative stress through ferryl hemoglobin reduction. Toxicology in Vitro. 2014, 28(5): 847-855.
19. Naihao Lu, Lian Yi, Qinqin Deng, Jinyang Li, Zhonghong Gao, Hailing Li*. The interaction between desferrioxamine and hemin: a potential toxicological implication. Toxicology in Vitro. 2012, 26 (5): 732-735.
20. Naihao Lu*, Wei Chen, Jingjie Zhu, Yi-Yuan Peng*. Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication. Toxicology in Vitro. 2012, 26 (1): 81-85.